Diversity and evolution of TIR-domain-containing proteins in bivalves and Metazoa: New insights from comparative genomics

The Toll/interleukin-1 receptor (TIR) domain has a fundamental role in the innate defence response of plants, vertebrate and invertebrate animals. Mostly found in the cytosolic side of membrane-bound receptor proteins, it mediates the intracellular signalling upon pathogen recognition via heterotypic interactions. Although a number of TIR-domain-containing (TIR-DC) proteins have been characterized in vertebrates, their evolutionary … Continue reading Diversity and evolution of TIR-domain-containing proteins in bivalves and Metazoa: New insights from comparative genomics

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