The oyster immunity

Oysters, the common name for a number of different bivalve molluscs, are the worldwide aquaculture species and also play vital roles in the function of ecosystem. As invertebrate, oysters have evolved an integrated, highly complex innate immune system to recognize and eliminate various invaders via an array of orchestrated immune reactions, such as immune recognition, … Continue reading The oyster immunity

Immunotoxicity of nanoparticle nTiO2 to a commercial marine bivalve species, Tegillarca granosa

The increasing production and extensive application of nanoparticles (NPs) inevitably leads to increased release of NPs into the marine environment and therefore poses a potential threat to marine organisms, especially the sessile benthic bivalves. However, the impacts of NPs on the immunity of commercial and ecological important bivalve species, Tegillarca granosa, still remain unknown to … Continue reading Immunotoxicity of nanoparticle nTiO2 to a commercial marine bivalve species, Tegillarca granosa

Molecular characterization and antibacterial activity of a phage-type lysozyme from the Manila clam, Ruditapes philippinarum

A phage-type lysozyme, designed as RpPLYZ, was cloned and characterized from the clam Ruditapes philippinarum. The full-length cDNA of RpPLYZ was of 699 bp with an open reading frame (ORF) of 534 bp, encoding a polypeptide of 177-amino acid with a calculated molecular mass of 19.6 kDa and an isoelectric point of 9.05. Multiple alignments and … Continue reading Molecular characterization and antibacterial activity of a phage-type lysozyme from the Manila clam, Ruditapes philippinarum

Responses of Mytilus galloprovincialis hemocytes to environmental strains of Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio vulnificus

Marine bivalves are exposed to different types of bacteria in the surrounding waters, in particular of the Vibrio genus. In the hemocytes of the mussel Mytilus spp. immune responses to different vibrios have been largely characterized. However, little information is available on the hemocyte responses to human pathogenic vibrios commonly detected in coastal waters and … Continue reading Responses of Mytilus galloprovincialis hemocytes to environmental strains of Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio vulnificus

Immune-related genes in gastropods and bivalves: a comparative overview

The biological diversity of molluscs and their adaptation to highly diverse environments offer a unique opportunity for studying the evolution of the innate immune system in invertebrates. This review provides an updated account about the progresses made over the past few years in the study of the molecular players involved in the recognition of pathogen … Continue reading Immune-related genes in gastropods and bivalves: a comparative overview

Differential expression of novel metabolic and immunological biomarkers in oysters challenged with a virulent strain of OsHV-1

Early lifestages of the Pacific oyster (Crassostrea gigas) are highly susceptible to infection by OsHV-1 μVar, but little information exists regarding metabolic or pathophysiological responses of larval hosts. Using a metabolomics approach, we identified a range of metabolic and immunological responses in oyster larvae exposed to OsHV-1 μVar; some of which have not previously been … Continue reading Differential expression of novel metabolic and immunological biomarkers in oysters challenged with a virulent strain of OsHV-1

A molluscan extracellular signal-regulated kinase is involved in host response to immune challenges in vivo and in vitro

Extracellular signal-regulated kinases (ERKs) are a group of highly conserved serine/threonine-specific protein kinases that function as important signaling intermediates in mitogen-activated protein kinase (MAPK) pathways, which are involved in a wide variety of cellular activities, including proliferation, inflammation and cytokine production. However, little is known about the roles of this kinase in mollusk immunity. In … Continue reading A molluscan extracellular signal-regulated kinase is involved in host response to immune challenges in vivo and in vitro