Antiviral defense and innate immune memory in the oyster

The Pacific oyster, Crassostrea gigas, is becoming a valuable model for investigating antiviral defense in the Lophotrochozoa superphylum. In the past five years, improvements to laboratory-based experimental infection protocols using Ostreid herpesvirus I (OsHV-1) from naturally infected C. gigas combined with next-generation sequencing techniques has revealed that oysters have a complex antiviral response involving the … Continue reading Antiviral defense and innate immune memory in the oyster

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The Voltage-Dependent Anion Channel (VDAC) of Pacific Oysters Crassostrea gigas Is Upaccumulated During Infection by the Ostreid Herpesvirus-1 (OsHV-1): an Indicator of the Warburg Effect

Voltage-dependent anion channel (VDAC) is a key mitochondrial protein. VDAC drives cellular energy metabolism by controlling the influx and efflux of metabolites and ions through the mitochondrial membrane, playing a role in its permeabilization. This protein exerts a pivotal role during the white spot syndrome virus (WSSV) infection in shrimp, through its involvement in a … Continue reading The Voltage-Dependent Anion Channel (VDAC) of Pacific Oysters Crassostrea gigas Is Upaccumulated During Infection by the Ostreid Herpesvirus-1 (OsHV-1): an Indicator of the Warburg Effect

Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas

In the last decade, a paradigm shift has emerged in comparative immunology. Invertebrates can no longer be considered to be devoid of specific recognition and immune memory. However, we still lack a comprehensive view of these phenomena and their molecular mechanisms across phyla, especially in terms of duration, specificity, and efficiency in a natural context. … Continue reading Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas

The Pacific oyster (Crassostrea gigas) Hsp70 modulates the Ostreid herpes virus 1 infectivity

The Ostreid herpes virus type 1 (OsHV-1) is one of the most devastating pathogen in oyster cultures. Among several factors, as food limitation, oxygen depletion, salinity and temperature variations, episodes of “summer mortality” of the Pacific oyster Crassostrea gigas have also been associated with OsHV-1 infection. Mortalities of C. gigas spat and juveniles have increased significantly … Continue reading The Pacific oyster (Crassostrea gigas) Hsp70 modulates the Ostreid herpes virus 1 infectivity

Sequence analysis of malacoherpesvirus proteins: Pan-herpesvirus capsid module and replication enzymes with an ancient connection to “Megavirales”

The order Herpesvirales includes animal viruses with large double-strand DNA genomes replicating in the nucleus. The main capsid protein in the best-studied family Herpesviridae contains a domain with HK97-like fold related to bacteriophage head proteins, and several virion maturation factors are also homologous between phages and herpesviruses. The origin of herpesvirus DNA replication proteins is … Continue reading Sequence analysis of malacoherpesvirus proteins: Pan-herpesvirus capsid module and replication enzymes with an ancient connection to “Megavirales”

Interaction entre l’huître creuse Crassostrea gigas et l’Ostréid herpèsvirus OsHV-1 : influence de la salinité et du pH

Crassostrea gigas est l’espèce d’huître la plus cultivée au monde. Depuis 2008, des évènements de mortalité massive touchent les huîtres âgées de moins d’un an en Europe et en Océanie et ont été associés à l’émergence d’un nouveau variant de l’Ostréid herpèsvirus type 1, OsHV-1 μvar. Les huîtres sont naturellement présentes dans les écosystèmes estuariens … Continue reading Interaction entre l’huître creuse Crassostrea gigas et l’Ostréid herpèsvirus OsHV-1 : influence de la salinité et du pH

Oysters under threat from deadly herpes virus that is spreading around the world

THE world could soon be facing an oyster shortage as a deadly herpes virus is threatening to devastate oyster populations. The virus known as Ostreid herpesvirus 1 (OsHV-1), is impacting Pacific oysters, which is the most popular species to eat due to their large size and experts are worried it could continue to spread around … Continue reading Oysters under threat from deadly herpes virus that is spreading around the world